Protein Family Models

This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily [1]. [1]. 15307895. The Hotdog fold: wrapping up a superfamily of thioesterases and. dehydratases.. Dillon SC, Bateman A;. BMC Bioinformatics 2004;5:109-109. (from Pfam)

Date:

2024-08-14

This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters. [1]. 9837940. The three-dimensional structure of 4-hydroxybenzoyl-CoA. thioesterase from Pseudomonas sp. Strain CBS-3.. Benning MM, Wesenberg G, Liu R, Taylor KL, Dunaway-Mariano D,. Holden HM;. J Biol Chem 1998;273:33572-33579.. [2]. 8805534. Structure of a dehydratase-isomerase from the bacterial pathway. for biosynthesis of unsaturated fatty acids: two catalytic. activities in one active site.. Leesong M, Henderson BS, Gillig JR, Schwab JM, Smith JL;. Structure 1996;4:253-264. (from Pfam)

Date:

2024-08-14

This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid [1]. These proteins are usually composed of a pair of tandem HotDog domains. This entry represents the N-terminal one of the pair. [1]. 7479856. Modification of the substrate specificity of an acyl-acyl. carrier protein thioesterase by protein engineering.. Yuan L, Voelker TA, Hawkins DJ;. Proc Natl Acad Sci U S A 1995;92:10639-10643.. [2]. 1621095. Fatty acid biosynthesis redirected to medium chains in. transgenic oilseed plants.. Voelker TA, Worrell AC, Anderson L, Bleibaum J, Fan C, Hawkins. DJ, Radke SE, Davies HM;. Science 1992;257:72-74.. [3]. 15531590. A structural model of the plant acyl-acyl carrier protein. thioesterase FatB comprised of two helix/4-stranded sheet. domains: The N-terminal domain containing residues that affect. specificity, the C-terminal domain containing catalytic. residues.. Mayer KM, Shanklin J;. J Biol Chem 2004; [Epub ahead of print] (from Pfam)

Date:

2024-08-14

acyl-CoA thioesterase catalyzes the hydrolysis of acyl-CoA esters to the free fatty acid and CoA; belongs to the Hotdog fold superfamily

Date:

2024-04-30

This model describes a subset of related acyl-CoA thioesterases that include several at least partially characterized proteins. YbgC is an acyl-CoA thioesterase associated with the Tol-Pal system. YbaW is part of the FadM regulon.

Date:

2021-05-12