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AAA family ATPase
Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system. (from Pfam)
SMC proteins Flexible Hinge Domain
This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction ([1]). [1]. 12411491. Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA. Hirano M, Hirano T;. EMBO J 2002;21:5733-5744. (from Pfam)
RecF/RecN/SMC N terminal domain
This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics [1]. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination. [1]. 10429180. Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Strunnikov AV, Jessberger R;. Eur J Biochem 1999;263:6-13. [2]. 9640531. SMC protein complexes and higher-order chromosome dynamics. Hirano T;. Curr Opin Cell Biol 1998;10:317-322. (from Pfam)
chromosome segregation protein SMC
SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle.
chromosome segregation protein SMC is required for chromosome condensation and partitioning
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