Protein Family Models for Protein (Select 544961140) - Protein Family Models

Select item 4257871.

helix-hairpin-helix domain-containing protein

Date:: 2024-08-14

Family Accession:: NF025873.5
Method:: HMM

Select item 4171942.

Homologous recombination is a crucial process in all living organisms. In bacteria, this process the RuvA, RuvB, and RuvC proteins are involved. More specifically the proteins process the Holliday junction DNA. RuvA is comprised of three distinct domains. The domain represents the C-terminal domain and plays a significant role in the ATP-dependent branch migration of the hetero-duplex through direct contact with RuvB [1]. Within the Holliday junction, the C-terminal domain makes no interaction with DNA [1]. [1]. 10890893. Crystal structure of the holliday junction DNA in complex with a single RuvA tetramer. Ariyoshi M, Nishino T, Iwasaki H, Shinagawa H, Morikawa K;. Proc Natl Acad Sci U S A 2000;97:8257-8262. (from Pfam)

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: DNA repair (GO:0006281)

Biological Process:: DNA recombination (GO:0006310)

Molecular Function:: four-way junction helicase activity (GO:0009378)

Cellular Component:: Holliday junction helicase complex (GO:0009379)

Date:: 2024-10-16

Family Accession:: NF019140.5
Method:: HMM

Select item 4125383.

OB-fold domain-containing protein

The N terminal domain of RuvA has an OB-fold structure. This domain forms the RuvA tetramer contacts [1]. [1]. 8832889. Crystal structure of DNA recombination protein RuvA and a model for its binding to the Holliday junction. Rafferty JB, Sedelnikova SE, Hargreaves D, Artymiuk PJ, Baker PJ, Sharples GJ, Mahdi AA, Lloyd RG, Rice DW;. Science 1996;274:415-421. (from Pfam)

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: DNA repair (GO:0006281)

Biological Process:: DNA recombination (GO:0006310)

Molecular Function:: four-way junction helicase activity (GO:0009378)

Date:: 2024-10-16

Family Accession:: NF013495.5
Method:: HMM

Select item 4048384.

new record, indexing in progress

Family Accession:

Select item 3971295.

new record, indexing in progress

Family Accession:

Select item 3893756.

new record, indexing in progress

Family Accession:

Select item 3581467.

new record, indexing in progress

Family Accession:

Select item 3524368.

new record, indexing in progress

Family Accession:

Select item 3482859.

new record, indexing in progress

Family Accession:

Select item 34298310.

Holliday junction branch migration protein RuvA

RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions.

Gene:: ruvA

GO Terms:

Molecular Function:: DNA helicase activity (GO:0003678)

Biological Process:: DNA repair (GO:0006281)

Biological Process:: DNA recombination (GO:0006310)

Molecular Function:: four-way junction helicase activity (GO:0009378)

Cellular Component:: Holliday junction helicase complex (GO:0009379)

Date:: 2024-05-16

Family Accession:: TIGR00084.2
Method:: HMM

Select item 33950011.

Holliday junction branch migration protein RuvA

Holliday junction branch migration protein RuvA is an ATP-dependent DNA helicase involved in branch migration of heteroduplex DNA in homologous recombination, by stimulating the ATPase activity of RuvB

Date:: 2024-12-19

Family Accession:: 11428141
Method:: Sparcle

Select item 1638112.

new record, indexing in progress

Family Accession:

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