Protein Family Models

This is a metal-binding protein which is involved in resistance to heavy-metal ions [1,2]. The protein forms a four-helix hooked hairpin, consisting of two long alpha helices each flanked by a shorter alpha helix. It binds a metal ion in a type-2 like centre [3]. It contains two copies of an LTXXQ motif. [1]. 9694902. Identification of a novel transcription regulator from Proteus mirabilis, PMTR, revealed a possible role of YJAI protein in balancing zinc in Escherichia coli. Noll M, Petrukhin K, Lutsenko S;. J Biol Chem. 1998;273:21393-21401. [2]. 7961470. Combined nickel-cobalt-cadmium resistance encoded by the ncc locus of Alcaligenes xylosoxidans 31A. Schmidt T, Schlegel HG;. J Bacteriol. 1994;176:7045-7054. [3]. 18992246. X-ray structure of the metal-sensor CnrX in both the apo- and copper-bound forms. Pompidor G, Maillard AP, Girard E, Gambarelli S, Kahn R, Coves J;. FEBS Lett. 2008;582:3954-3958. (from Pfam)

Date:

2024-10-16

This protein family includes two copies of a five residue motif is found in a number of bacterial proteins bearing similarity to the protein CpxP (Swiss:P32158). This is a periplasmic protein that aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH [1]. Another member of this family, Spy (Swiss:P77754) is also a periplasmic protein that may be involved in the response to stress [2]. The homology between CpxP and Spy may indicate that these two proteins are functionally related [1]. [1]. 9473036. CpxP, a stress-combative member of the Cpx regulon. Danese PN, Silhavy TJ;. J Bacteriol 1998;180:831-839. [2]. 9068658. A new periplasmic protein of Escherichia coli which is synthesized in spheroplasts but not in intact cells. Hagenmaier S, Stierhof YD, Henning U;. J Bacteriol 1997;179:2073-2076. [3]. 20799348. The crystal structure Escherichia coli Spy. Kwon E, Kim DY, Gross CA, Gross JD, Kim KK;. Protein Sci. 2010; [Epub ahead of print] (from Pfam)

Date:

2024-10-16

CpxP family protein such as the cell-envelope stress modulator CpxP, which acts as an auxiliary protein in the Cpx two-component envelope stress response system, helps modulate the Cpx response system's response to some inducers, and contains LTXXQ motifs

Date:

2019-09-11

Date:

2020-10-26