Protein Family Models for Protein (Select 545591825) - Protein Family Models

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Items: 4

Select item 4161841.

succinylglutamate desuccinylase/aspartoacylase family protein

This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in Swiss:P45381 lead to Canavan disease disease [1]. This family is probably structurally related to Pfam:PF00246 (Bateman A pers. obs.). [1]. 8252036. Cloning of the human aspartoacylase cDNA and a common missense. mutation in Canavan disease.. Kaul R, Gao GP, Balamurugan K, Matalon R;. Nat Genet 1993;5:118-123. (from Pfam)

GO Terms:

Molecular Function:: hydrolase activity, acting on ester bonds (GO:0016788)

Date:: 2024-08-14

Family Accession:: NF016817.5
Method:: HMM

Select item 3916192.

new record, indexing in progress

Family Accession:

Select item 3531323.

new record, indexing in progress

Family Accession:

Select item 1404134.

M14 family metallopeptidase

M14 family metallopeptidase is a zinc-binding carboxypeptidase which hydrolyzes a single, C-terminal amino acid from a polypeptide chain, and has a recognition site for the free C-terminal carboxyl group