Protein Family Models

This region is found in Pectate lyase L from Erwinia chrysanthemi (Pel9A) and similar bacterial and fungal proteins. Pel9A shows endo-cleaving activity on polygalacturonate or partially methylated pectin and has an important role in soft -rot disease. This region forms a parallel beta helix domain [1]. [1]. 14670977. The crystal structure of pectate lyase Pel9A from Erwinia chrysanthemi. Jenkins J, Shevchik VE, Hugouvieux-Cotte-Pattat N, Pickersgill RW;. J Biol Chem. 2004;279:9139-9145. (from Pfam)

Date:

2024-10-28

This domain, previously known as DUF4990, is found at the C terminus of a group of proteins mainly from Bacteroides species, including the rhamnogalacturonan lyase BT_4170 from Bacteroides thetaiotaomicron [1,2]. [1]. 29255254. Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides. Luis AS, Briggs J, Zhang X, Farnell B, Ndeh D, Labourel A, Basle A, Cartmell A, Terrapon N, Stott K, Lowe EC, McLean R, Shearer K, Schuckel J, Venditto I, Ralet MC, Henrissat B, Martens EC, Mosimann SC, Abbott DW, Gilbert HJ;. Nat Microbiol. 2018;3:210-219. [2]. 34420703. Discrete genetic loci in human gut Bacteroides thetaiotaomicron confer pectin metabolism. Li M, Li S, Guo X, Guo C, Wang Y, Du Z, Zhang Z, Xie C, Ding K;. Carbohydr Polym. 2021;272:118534. (from Pfam)

Date:

2024-10-16

Beta_helix and DUF4990 domain-containing protein

Date:

2017-03-02