Protein Family Models

Members of this family include multiple membrane-spanning proteins associated with proton translocation. These include NADH ubiquinone oxidoreductase subunits NuoL, NuoN, and NuoM, hydrogenase components HyfB, HyfD, and HyfF, as well as subunits of carbon monoxide dehydrogenase, F420 dehydrogenase, etc, as well as Na+/H+ antiporter subunits.

Date:

2024-10-16

This sub-family represents an amino terminal extension of Pfam:PF00361. Only NADH-Ubiquinone chain 5 and eubacterial chain L are in this family. This sub-family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane. [1]. 1470679. The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains. Walker JE;. Q Rev Biophys 1992;25:253-324. (from Pfam)

Date:

2024-10-16

NADH-quinone oxidoreductase subunit L is a component of the NADH dehydrogenase I complex, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

Date:

2024-11-12

TIGR01972 describes the 12th (based on E. coli) structural gene, L, of bacterial NADH dehydrogenase I, as well as chain 5 of the corresponding mitochondrial complex I and subunit 5 (or F) of the chloroplast NAD(P)H-plastoquinone dehydrogenase complex.. The complex to which this protein belongs may rely on ubiquinone as electron acceptor (EC 1.6.5.3), or allow more general use of other quinones such as menaquinone (EC 1.6.5.11).

Date:

2021-05-12

Gene:

nuoL

Date:

2021-07-22