Protein Family Models for Protein (Select 550748323) - Protein Family Models

Select item 4220151.

HD domains are metal dependent phosphohydrolases. [1]. 9868367. The HD domain defines a new superfamily of metal-dependent phosphohydrolases. Aravind L, Koonin EV;. Trends Biochem Sci 1998;23:469-472. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF024423.5
Method:: HMM

Select item 4217042.

YfbR-like 5'-deoxynucleotidase

This entry contains Escherichia coli (strain K12) YfbR. It a 5'-deoxynucleotidase that functions as a dCMP phosphohydrolase in a salvage pathway for the synthesis of dUMP in a dcd/deoA mutant [1]. YfbR contains a conserved HD domain [2]. YfbR has phosphatase activity with deoxyribonucleoside 5'-monophosphates and does not hydrolyze ribonucleotides or deoxyribonucloside 3'-monophosphates [2,3]. Crystal structures of YfbR have been solved, it was suggested that the biological unit is a dimer [4]. This family also includes phage HD domain-containing hydrolase-like enzymes, such as A0A2H5BHG9 and A0A2L0V156 from Acinetobacter phage SH-Ab15497 [5], which are associated with PurZ, an enzyme that catalyses the synthesis of diaminopurine (Z), a DNA modification that gives phages an advantage for evading host restriction enzymes activity. They have 2'-deoxyadenine 5'-triphosphate triphosphohydrolase (dATPase) activity and catalyse the hydrolysis of 2'-deoxyadenine 5'-triphosphate dATP to 2'-deoxyadenine (dA) and triphosphate. These enzymes are highly specific for dATP and also catalyse the hydrolysis of dADP and dAMP into dA, releasing pyrophosphate and phosphate, respectively. Thus, these dATPases facilitate the synthesis of Z-genome synthesis removing dATP and dADP from the nucleotide pool of the host [5]. [1]. 17827303. The deoxycytidine pathway for thymidylate synthesis in Escherichia coli. Weiss B;. J Bacteriol. 2007;189:7922-7926. [2]. 15489502. General enzymatic screens identify three new nucleotidases in Escherichia coli. Biochemical characterization of SurE, YfbR, and YjjG. Proudfoot M, Kuznetsova E, Brown G, Rao NN, Kita. TRUNCATED at 1650 bytes (from Pfam)

Date:: 2024-10-16

Family Accession:: NF024319.5
Method:: HMM

Select item 4135803.

HD domain-containing protein

Date:: 2024-10-16

Family Accession:: NF014069.5
Method:: HMM

Select item 4029614.