Protein Family Models

This family represents a bacterial outer membrane lipoprotein that is necessary for signalling by the Cpx pathway [1]. This pathway responds to cell envelope disturbances and increases the expression of periplasmic protein folding and degradation factors. While the molecular function of the NlpE protein is unknown, it may be involved in detecting bacterial adhesion to abiotic surfaces. In Escherichia coli and Salmonella typhi, NlpE is also known to confer copper tolerance in copper-sensitive strains of Escherichia coli, and may be involved in copper efflux and delivery of copper to copper-dependent enzymes [2]. This domain is found at the C-terminus of the NlpE protein [3]. [1]. 11830644. Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathway. Otto K, Silhavy TJ;. Proc Natl Acad Sci U S A 2002;99:2287-2292. [2]. 7635807. Identification of cutC and cutF (nlpE) genes involved in copper tolerance in Escherichia coli. Gupta SD, Lee BT, Camakaris J, Wu HC;. J Bacteriol 1995;177:4207-4215. [3]. 17698001. Structural studies of the Cpx pathway activator NlpE on the outer membrane of Escherichia coli. Hirano Y, Hossain MM, Takeda K, Tokuda H, Miki K;. Structure. 2007;15:963-976. (from Pfam)

Date:

2024-10-16

This entry is encoded within type III secretion operons. The protein has been characterised as a chaperone for the outer membrane pore component YscC. YscW is a lipoprotein which is itself localized to the outer membrane and, it is believed, facilitates the oligomerisation and localisation of YscC. (from Pfam)

Date:

2024-08-14

Small domain family found in proteins of of unknown function. Some are secreted (e.g. Swiss:O25998) and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene. Over-expression in L.amazonensis increases virulence (Swiss:O43987; [1]). A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond. [1]. 10403759. Leishmania: overexpression and comparative structural analysis of the stage-regulated meta 1 gene. Uliana SR, Goyal N, Freymuller E, Smith DF;. Exp Parasitol 1999;92:183-191. [2]. 12625841. New Knowledge from Old: In silico discovery of novel protein domains in Streptomyces coelicolor. Yeats C, Bentley S, Bateman A;. BMC Microbiol 2003;3:3-3. (from Pfam)

Date:

2024-10-16