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DEXQ-box helicase domain of Suv3
This entry represents the DEXQ-box helicase domain of Suv3 [1]. Paper describing PDB structure 3rc3. [1]. 22101826. Human Suv3 protein reveals unique features among SF2 helicases. Jedrzejczak R, Wang J, Dauter M, Szczesny RJ, Stepien PP, Dauter Z;. Acta Crystallogr D Biol Crystallogr. 2011;67:988-996. (from Pfam)
DSHCT (NUC185) domain
This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases [1]. [1]. 15112237. Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire. Staub E, Fiziev P, Rosenthal A, Hinzmann B;. Bioessays 2004;26:567-581. (from Pfam)
DEAD/DEAH box helicase family protein
DEAD/DEAH box helicase
Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. [1]. 10322435. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. de la Cruz J, Kressler D, Linder P;. Trends Biochem Sci 1999;24:192-198. [2]. 9862990. The DEAD box RNA helicase family in Arabidopsis thaliana. Aubourg S, Kreis M, Lecharny A;. Nucleic Acids Res 1999;27:628-636. (from Pfam)
helicase-related protein
The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase. (from Pfam)
DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA
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