Protein Family Models

This family of proteins is functionally uncharacterised. This family of proteins is found primarily in bacteria. Proteins in this family are typically between 197 and 228 amino acids in length. This family appears to be distantly related to Pfam:PF13338 suggesting proteins in this family may be an antitoxin component of a toxin/antitoxin system. (from Pfam)

Date:

2024-08-14

AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is Pfam:PF13338 [1]. [1]. 24465005. A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism. Dy RL, Przybilski R, Semeijn K, Salmond GP, Fineran PC;. Nucleic Acids Res. 2014;42:4590-4605. (from Pfam)

Date:

2024-10-16