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ArsR family transcriptional regulator
Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition. [1]. 9466913. Crystal structure of the cyanobacterial metallothionein. repressor SmtB: a model for metalloregulatory proteins.. Cook WJ, Kar SR, Taylor KB, Hall LM;. J Mol Biol 1998;275:337-346. (from Pfam)
ArsR/SmtB family transcription factor
ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis
metalloregulator ArsR/SmtB family transcription factor
Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.
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