Protein Family Models for Protein (Select 556277261) - Protein Family Models

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Links from Protein

Items: 6

Select item 4184131.

helix-turn-helix domain-containing protein

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Biological Process:: regulation of DNA-templated transcription (GO:0006355)

Date:: 2024-08-14

Family Accession:: NF020897.5
Method:: HMM

Select item 4135692.

IclR family transcriptional regulator C-terminal domain-containing protein

This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. These proteins have a Helix-Turn-Helix motif at the N-terminus. However this family covers the C-terminal region that binds to regulatory substrates including Glyoxylate, allantoin/ate, indole, aromatic hydrocarbons, sugar acids, succinic semialdehyde, benzoate derivatives, ascorbic acid, glycerol-3-phosphate, glyceraldehyde-3-phosphate and pyruvate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 1995429. Primary structure of the intergenic region between aceK and iclR in the Escherichia coli chromosome. Galinier A, Bleicher F, Negre D, Perriere G, Duclos B, Cozzone AJ, Cortay JC;. Gene 1991;97:149-150. [2]. 3225846. Structure and regulation of controlling sequences for the Streptomyces coelicolor glycerol operon. Smith CP, Chater KF;. J Mol Biol 1988;204:569-580. (from Pfam)