Protein Family Models

The members of this family are similar to the hypothetical protein yhhN expressed by E. coli (Swiss:P37616). Many are annotated as possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues. A human member of this family, formerly known as TMEM86B, is a lysoplasmalogenase that catalyzes the hydrolysis of the vinyl ether bond of lysoplasmalogen[1]. Putative conserved active site residues have been proposed for the YhhN family [2]. [1]. 21515882. Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen. Wu LC, Pfeiffer DR, Calhoon EA, Madiai F, Marcucci G, Liu S, Jurkowitz MS;. J Biol Chem. 2011;286:24916-24930. [2]. 26335199. Large-scale determination of previously unsolved protein structures using evolutionary information. Ovchinnikov S, Kinch L, Park H, Liao Y, Pei J, Kim DE, Kamisetty H, Grishin NV, Baker D;. Elife. 2015; [Epub ahead of print] (from Pfam)

Date:

2024-10-16

lysoplasmalogenase, a membrane protein such as Legionella pneumophila YhhN, catalyzes the hydrolytic cleavage of the vinyl-ether bond of lysoplasmalogen, which is formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens

Date:

2016-11-07