Protein Family Models

This family contains several bacterial flagellar FliT proteins. The flagellar proteins FlgN and FliT have been proposed to act as substrate specific export chaperones, facilitating incorporation of the enterobacterial hook-associated axial proteins (HAPs) FlgK/FlgL and FliD into the growing flagellum. In Salmonella typhimurium flgN and fliT mutants, the export of target HAPs is reduced, concomitant with loss of unincorporated flagellin into the surrounding medium [1]. [1]. 11169117. Substrate complexes and domain organization of the Salmonella flagellar export chaperones FlgN and FliT. Bennett JC, Thomas J, Fraser GM, Hughes C;. Mol Microbiol 2001;39:781-791. (from Pfam)

Gene:

fliT

Date:

2024-10-16

Binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family

Gene:

fliT

Date:

2022-07-20

flagella biosynthesis regulatory protein FliT is a dual-function protein that regulates the transcription of class 2 flagellar operons and also acts as an export chaperone for the filament-capping protein FliD

Date:

2021-01-12