Protein Family Models

This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits [1]. This family is structurally homologous to nucleotidyltransferases. [1]. 22829778. RsfA (YbeB) proteins are conserved ribosomal silencing factors. Hauser R, Pech M, Kijek J, Yamamoto H, Titz B, Naeve F, Tovchigrechko A, Yamamoto K, Szaflarski W, Takeuchi N, Stellberger T, Diefenbacher ME, Nierhaus KH, Uetz P;. PLoS Genet. 2012;8:e1002815. (from Pfam)

Date:

2024-10-16

ribosome silencing factor RsfS represses translation by preventing the association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes

Date:

2018-01-03

This model describes a widely distributed family of bacterial proteins related to iojap from plants. It includes RsfS(YbeB) from E. coli. The gene iojap is a pattern-striping gene in maize, reflecting a chloroplast development defect in some cells. The conserved function of this protein is to silence ribosomes by binding the ribosomal large subunit and impairing joining with the small subunit in response to nutrient stress. Note that RsfS (starvation) is an author-endorsed change from the published symbol RsfA, which conflicted with previously published gene symbols.

Gene:

rsfS

Date:

2021-04-27