Protein Family Models

CntA from Staphylococcus aureus, the founding member of this family, binds the holo-staphylopine, that is, the metallophore with a chelated metal. The tailoring of staphylopine-like metallophores likely differs some among the species in which the CntABCDE ABC transporter is present. Metals that can chelated and then imported include zinc, nickel, and copper. Members of this family belong to a broader family (see TIGR02294) that also includes NikA from Escherichia coli.

Gene:

cntA

Date:

2024-09-24

The borders of this family are based on the PDBSum definitions of the domain edges for Swiss:P06202. (from Pfam)

Date:

2024-08-14

Members of this family are periplasmic nickel-binding proteins of nickel ABC transporters. Most appear to be lipoproteins. This protein was previously (circa 2003) thought to mediate binding to nickel through water molecules, but more recently understood to involve a chelating organic molecules that act as a metallophore. Butane-1,2,4-tricarboxylate was suggested as the metallophore in Escherichia coli, while known opine metallophores transported by members of this family include staphylopine in Staphylococcus aureus. Staphylopine ABC transporter substrate-binding lipoproteins are known as CntA.

Gene:

nikA

Date:

2024-09-23