Protein Family Models

The family includes the protease PfpI Swiss:Q51732 [1]. This domain is also found in transcriptional regulators such as Swiss:Q9RJG8. [1]. 8626329. Sequence, expression in Escherichia coli, and analysis of the gene encoding a novel intracellular protease (PfpI) from the hyperthermophilic archaeon Pyrococcus furiosus. Halio SB, Blumentals II, Short SA, Merrill BM, Kelly RM;. J Bacteriol 1996;178:2605-2612. [2]. 15784968. AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus. Ohnishi Y, Yamazaki H, Kato JY, Tomono A, Horinouchi S;. Biosci Biotechnol Biochem. 2005;69:431-439. (from Pfam)

Date:

2024-10-16

HchA (Hsp31), a DJ-1 family protein, previously was thought to be a deglycase, but now is thought to be a one-step, glutathione-independent glyoxalase (glyoxalase III) that prevents glycation by reducing levels of the toxic metabolic byproduct methylglyoxal.

Gene:

hchA

Date:

2023-12-08

protein deglycase HchA deglycates cysteine, arginine and lysine residues in proteins, reactivating these proteins by reversing glycation by methylglyoxals or glyoxals and releasing lactate or glycolate, respectively

Date:

2016-12-16