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AIR carboxylase family protein
Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain. [1]. 10574791. Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. Mathews II, Kappock TJ, Stubbe J, Ealick SE;. Structure Fold Des 1999;7:1395-1406. (from Pfam)
5-(carboxyamino)imidazole ribonucleotide mutase
Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This model represents PurK, an N5-CAIR mutase.
5-(carboxyamino)imidazole ribonucleotide mutase catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR), a step in de novo purine nucleotide biosynthesis
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