Protein Family Models

ZnuA includes periplasmic solute binding proteins such as TroA that interacts with an ATP-binding cassette transport system in Treponema pallidum [1]. ZnuA is part of the bacterial zinc-uptake complex ZnuABC, whose components are the following families, ZinT, Pfam:PF09223, Pfam:PF00950, Pfam:PF00005, all of which are regulated by the transcription-regulator family FUR, Pfam:PF01475. ZinT acts as a Zn2+-buffering protein that delivers Zn2+ to ZnuA (TroA), a high-affinity zinc-uptake protein. In Gram-negative bacteria the ZnuABC transporter system ensures an adequate import of zinc in Zn2+-poor environments, such as those encountered by pathogens within the infected host [2,3]. [1]. 10404217. Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone. Lee YH, Deka RK, Norgard MV, Radolf JD, Hasemann CA;. Nat Struct Biol 1999;6:628-633. [2]. 21338480. Role of ZnuABC and ZinT in Escherichia coli O157:H7 zinc acquisition and interaction with epithelial cells. Gabbianelli R, Scotti R, Ammendola S, Petrarca P, Nicolini L, Battistoni A;. BMC Microbiol. 2011;11:36. [3]. 24128931. The Salmonella enterica ZinT structure, zinc affinity and interaction with the high-affinity uptake protein ZnuA provide insight into the management of periplasmic zinc. Ilari A, Alaleona F, Tria G, Petrarca P, Battistoni A, Zamparelli C, Verzili D, Falconi M, Chiancone E;. Biochim Biophys Acta. 2014;1840:535-544. (from Pfam)

Date:

2024-10-16

Members of this family, such as SloC from Streptococcus mutans, are lipoproteins found in metal ABC transporter cassettes. The panel of metals bound and transported can vary from member to member but typically includes manganese, and names provided in publications differ as well. It appears that some members of this so-called LraI family of lipoproteins moonlight as adhesins.

Date:

2022-06-14

metal ABC transporter substrate-binding lipoprotein functions as the initial receptor in ABC transport of metal ions and as surface adhesin in some eubacterial species

Date:

2023-02-21

Gene:

psaA

Date:

2017-12-19