Protein Family Models

This is a domain of unknown function that is found either as a standalone protein or in combination with other domains. Members of this family possess a highly conserved LSAXXG motif that may constitute an active site. This domain may be distantly related to oxidative stress response YaaA proteins. (from Pfam)

Date:

2024-10-16

YaaA is a key element of the stress response to H2O2. It acts by reducing the level of intracellular iron levels after peroxide stress, thereby attenuating the Fenton reaction and the DNA damage that this would cause [1]. The molecular mechanism of action is not known. [1]. 21378183. The YaaA protein of the Escherichia coli OxyR regulon lessens hydrogen peroxide toxicity by diminishing the amount of intracellular unincorporated iron. Liu Y, Bauer SC, Imlay JA;. J Bacteriol. 2011;193:2186-2196. (from Pfam)

Gene:

yaaA

Date:

2024-10-16

Gene:

yaaA

Date:

2020-10-26

Gene:

yaaA

Date:

2020-10-26

peroxide stress protein YaaA lowers the intracellular level of iron and therefore reduces toxicity of hydogen peroxide via an unknown mechanism

Date:

2023-02-21