Protein Family Models

MalF is a component of the maltose uptake system found in Proteobacteria, an ATP-binding cassette (ABC) transporter. This protein is composed of eight transmembrane (TM) helices and folds in a way its concave surface faces the similar assembly of MalG to enclose the maltose. This entry represents the first TM helices of this structure, which are located N-terminal to the large periplasmic loop (P2, Pfam:PF14785) [1]. Paper describing PDB structure 2r6g. [1]. 18033289. Crystal structure of a catalytic intermediate of the maltose transporter. Oldham ML, Khare D, Quiocho FA, Davidson AL, Chen J;. Nature. 2007;450:515-521. Paper describing PDB structure 3fh6. [2]. 19250913. Alternating access in maltose transporter mediated by rigid-body rotations. Khare D, Oldham ML, Orelle C, Davidson AL, Chen J;. Mol Cell. 2009;33:528-536. [3]. 24145421. Structural basis for substrate specificity in the Escherichia coli maltose transport system. Oldham ML, Chen S, Chen J;. Proc Natl Acad Sci U S A. 2013;110:18132-18137. (from Pfam)

Date:

2024-10-16

This is the second periplasmic domain (P2 domain) of the maltose transport system permease protein MalF [1-2]. [1]. 21825153. Snapshots of the maltose transporter during ATP hydrolysis. Oldham ML, Chen J;. Proc Natl Acad Sci U S A. 2011;108:15152-15156. [2]. 18033289. Crystal structure of a catalytic intermediate of the maltose transporter. Oldham ML, Khare D, Quiocho FA, Davidson AL, Chen J;. Nature. 2007;450:515-521. (from Pfam)

Date:

2024-10-16

The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices. (from Pfam)

Date:

2024-08-14

sugar transporter permease similar to MalF, which is one of the two integral inner membrane subunits (MalFG) of the maltose ABC transport complex (MalFGKE); the MalFG subunits form a heterodimeric translocation pore with a dimer of the ATPase subunit (MalK)

Date:

2017-02-03

Functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis

Gene:

malF

Date:

2021-08-31