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aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme
alpha-hydroxyketone-type quorum-sensing autoinducer synthase
The PLP-dependent enzymes CAI-1 synthase from Vibrio cholerae and LAI-1 synthase from Legionella pneumophila produce alpha-hydroxyketone family quorum-sensing autoinducers. These autoinducers differ from the N-acyl-homoserine lactones of the AI-1 family, and are distinct enough that the two quorum-sensing systems can operate independently in the same organism. CqsA in V. cholerae (Cholerae Quorum-Sensing Autoinducer synthase produces (S)-3-hydroxytridecan-4-one, while LqsA in Legionella produces 3-hydroxypentadecan-4-one.
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