Protein Family Models for Protein (Select 639325297) - Protein Family Models

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Links from Protein

Items: 9

Select item 4237461.

EF-hand domain-containing protein

GO Terms:

Molecular Function:: calcium ion binding (GO:0005509)

Date:: 2024-08-14

Family Accession:: NF024600.5
Method:: HMM

Select item 4220372.

EF-hand domain

GO Terms:

Molecular Function:: calcium ion binding (GO:0005509)

Date:: 2024-08-14

Family Accession:: NF024797.5
Method:: HMM

Select item 4110773.

EF-hand domain-containing protein

The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes. [1]. 1602495. Evolution of EF-hand calcium-modulated proteins. II. Domains of several subfamilies have diverse evolutionary histories. Nakayama S, Moncrief ND, Kretsinger RH;. J Mol Evol 1992;34:416-448. [2]. 1618836. Comparison of terbium (III) luminescence enhancement in mutants of EF hand calcium binding proteins. Hogue CW, MacManus JP, Banville D, Szabo AG;. J Biol Chem 1992;267:13340-13347. [3]. 2401372. EF-hand motifs in inositol phospholipid-specific phospholipase C. Bairoch A, Cox JA;. FEBS Lett 1990;269:454-456. [4]. 7743133. The evolving model of calmodulin structure, function and activation. Finn BE, Forsen S;. Structure 1995;3:7-11. (from Pfam)

GO Terms:

Molecular Function:: calcium ion binding (GO:0005509)

Date:: 2024-10-16

Family Accession:: NF012266.5
Method:: HMM

Select item 4010604.