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nitroreductase family protein
The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds. [1]. 8846223. Crystal structure of NADH oxidase from Thermus thermophilus. Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD. Nat Struct Biol 1995;2:1109-1114. [2]. 17331467. In silico identification of a new group of specific bacterial and fungal nitroreductases-like proteins. de Oliveira IM, Henriques JA, Bonatto D;. Biochem Biophys Res Commun. 2007;355:919-925. (from Pfam)
5,6-dimethylbenzimidazole synthase
A previously published hypothesis that BluB, involved in cobalamin biosynthesis, is EC 1.16.8.1 (cob(II)yrinic acid a,c-diamide reductase) is now contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis. The BluB protein is related to the nitroreductase family (PF0881).
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