Protein Family Models

A pan-bacterial lineage of proteins. Nitrate assimilation protein, NarQ, [1] and FdhD (Swiss:P32177) are required for formate dehydrogenase activity. Structurally, they possess a deaminase fold with a characteristic binding pocket, suggesting that they might bind a nucleotide or related molecule allosterically to regulate the formate dehydrogenase catalytic subunit [2]. [1]. 7860592. Identification and isolation of a gene required for nitrate assimilation and anaerobic growth of Bacillus subtilis. Glaser P, Danchin A, Kunst F, Zuber P, Nakano MM;. J Bacteriol 1995;177:1112-1115. [2]. 21890906. Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems. Iyer LM, Zhang D, Rogozin IB, Aravind L;. Nucleic Acids Res. 2011; [Epub ahead of print] (from Pfam)

Date:

2024-10-16

formate dehydrogenase accessory sulfurtransferase FdhD is involved in the production or activity of formate dehydrogenase-H

Date:

2022-11-18

FdhD in E. coli and NarQ in B. subtilis are required for the activity of formate dehydrogenase. The gene name in B. subtilis reflects the requirement of the neighboring gene narA for nitrate assimilation, for which NarQ is not required. In some species, the gene is associated not with a known formate dehydrogenase but with a related putative molybdopterin-binding oxidoreductase. A reasonable hypothesis is that this protein helps prepare a required cofactor for assembly into the holoenzyme.

Gene:

fdhD

Date:

2024-06-14