Protein Family Models

This PUA-like domain is found at the N-terminus of SAM-dependent methyltransferases [1]. [1]. 16260766. The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii. Sun W, Xu X, Pavlova M, Edwards AM, Joachimiak A, Savchenko A, Christendat D;. Protein Sci. 2005;14:3121-3128. (from Pfam)

Date:

2024-10-16

This family appears to have methyltransferase activity. (from Pfam)

Date:

2024-08-14

This family appears to be a methyltransferase domain. (from Pfam)

Date:

2024-08-14

Members of this family are S-adenosylmethionine-dependent methyltransferases from gamma-proteobacterial species. The diversity in the roles of methylation is matched by the almost bewildering number of methyltransferase enzymes that catalyse the methylation reaction. Although several classes of methyltransferase enzymes are known, the great majority of methylation reactions are catalysed by the S-adenosylmethionine-dependent methyltransferases. [1]. 12504684. SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold. Martin JL, McMillan FM;. Curr Opin Struct Biol. 2002;12:783-793. (from Pfam)

Date:

2024-10-16

RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyse methylation of the exocyclic N2 amine of 7-methylguanosine [1]. [1]. 17284461. Biochemical and Genetic Analysis of RNA Cap Guanine-N2 Methyltransferases from Giardia lamblia and Schizosaccharomyces pombe. Hausmann S, Ramirez A, Schneider S, Schwer B, Shuman S;. Nucleic Acids Res. 2007; [Epub ahead of print] (from Pfam)

Date:

2024-10-16

This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences. [1]. 8226664. Cotranscription of two genes necessary for ribosomal protein L11 methylation (prmA) and pantothenate transport (panF) in Escherichia coli K-12. Vanet A, Plumbridge JA, Alix JH;. J Bacteriol 1993;175:7178-7188. (from Pfam)

Date:

2024-10-16

This domain is found in ribosomal RNA small subunit methyltransferase C (eg Swiss:P44453) as well as other methyltransferases (eg Swiss:Q53742). (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast (Swiss:P38793) suggesting this protein may be involved in methionine biosynthesis, transport and/or utilisation [1]. [1]. 7557397. Sequence of the met-10+ locus of Neurospora crassa: homology to a sequence of unknown function in Saccharomyces cerevisiae chromosome 8. Chow CM, Kang S, Metzenberg RL, RajBhandary UL;. Gene 1995;162:111-115. (from Pfam)

Date:

2024-10-16

This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesised that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping [2]. [1]. 10983982. RNA methylation under heat shock control. Bugl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U;. Mol Cell 2000;6:349-360. [2]. 8385698. Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and lambda 2 protein of reovirus. Koonin EV;. J Gen Virol 1993;74:733-740. (from Pfam)

Date:

2024-10-16