Protein Family Models

The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease [1]. [1]. 11897024. Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors. Iyer LM, Koonin EV, Aravind L;. Genome Biol 2002;3:RESEARCH0012. [2]. 9299332. The X-ray structure of the DNA-binding domain from the Saccharomyces cerevisiae cell-cycle transcription factor Mbp1 at 2.1 A resolution. Taylor IA, Treiber MK, Olivi L, Smerdon SJ;. J Mol Biol 1997;272:1-8. (from Pfam)

Date:

2024-10-16

KilA-N domain-containing protein is a DNA-binding protein such as Saccharomyces cerevisiae transcription factor PHD1 that functions in pseudohyphal growth

Date:

2024-08-29