Protein Family Models

Date:

2024-08-14

The 3-dehydroquinate synthase EC:4.6.1.3 domain is present in isolation in various bacterial 3-dehydroquinate synthases and also present as a domain in the pentafunctional AROM polypeptide Swiss:P07547 [2]. 3-dehydroquinate (DHQ) synthase catalyses the formation of dehydroquinate (DHQ) and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate [1]. This reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. [1]. 9613570. Cloning and characterisation of the Neisseria gonorrhoeae aroB. gene.. Barten R, Meyer TF;. Mol Gen Genet 1998;258:34-44.. Discusses the pentafunctional AROM multi-domain protein, which. possesses a shikimate 5-dehydrogenase enzyme. The AROM protein. catalyses steps two to six in the shikimate pathway in many. microbial eukaryotes.. [2]. 7556173. The molecular biology of multidomain proteins. Selected. examples.. Hawkins AR, Lamb HK;. Eur J Biochem 1995;232:7-18. (from Pfam)

Date:

2024-08-14

This HMM represents 3-dehydroquinate synthase, the enzyme catalyzing the second of seven steps in the shikimate pathway of chorismate biosynthesis. Chorismate is the last common intermediate in the biosynthesis of all three aromatic amino acids.

Gene:

aroB

Date:

2024-05-28

3-dehydroquinate synthase family protein similar to 3-dehydroquinate synthase that catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate to dehydroquinate in the shikimate pathway

Date:

2024-08-07