Protein Family Models

This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily [1]. This domain represents the C-terminal domain in a pair of HotDog domains, usually found with Pfam:PF13622. [1]. 15307895. The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases. Dillon SC, Bateman A;. BMC Bioinformatics 2004;5:109-109. (from Pfam)

Date:

2024-10-16

This family contains a wide variety of enzymes, principally acyl-CoA thioesterases. These enzymes are part of the Hotdog fold superfamily [1]. This entry is usually found as the N-terminal part of a pair of HotDog domains. [1]. 15307895. The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases. Dillon SC, Bateman A;. BMC Bioinformatics 2004;5:109-109. (from Pfam)

Date:

2024-10-16

This family represents the thioesterase II domain. Two copies of this domain are found in a number of acyl-CoA thioesterases. [1]. 9299485. A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef. Watanabe H, Shiratori T, Shoji H, Miyatake S, Okazaki Y, Ikuta K, Sato T, Saito T;. Biochem Biophys Res Commun 1997;238:234-239. [2]. 1645722. Cloning, sequencing, and characterization of Escherichia coli thioesterase II. Naggert J, Narasimhan ML, DeVeaux L, Cho H, Randhawa ZI, Cronan JE Jr, Green BN, Smith S;. J Biol Chem 1991;266:11044-11050. (from Pfam)

Date:

2024-10-16

acyl-coenzyme A thioesterase II catalyzes the hydrolysis of acyl-CoAs to the free fatty acid and CoA

Date:

2017-02-03

Gene:

tesB

Date:

2020-10-26

Function: hydrolyzes a broad range of acyl-CoA thioesters. Physiological function is not known. Subunit: homotetramer.

Gene:

tesB

Date:

2022-03-28