Protein Family Models for Protein (Select 654544545) - Protein Family Models

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Links from Protein

Items: 7

Select item 4206771.

helix-turn-helix domain-containing protein

GO Terms:

Molecular Function:: DNA-binding transcription factor activity (GO:0003700)

Biological Process:: regulation of DNA-templated transcription (GO:0006355)

Molecular Function:: sequence-specific DNA binding (GO:0043565)

Date:: 2024-08-14

Family Accession:: NF024242.5
Method:: HMM

Select item 4113562.

AraC family transcriptional regulator

In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (Pfam:PF00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerisation domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilised when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added [1-2]. [1]. 9600836. Apo-AraC actively seeks to loop.. Seabold RR, Schleif RF;. J Mol Biol 1998;278:529-538.. [2]. 9600837. Arm-domain interactions in AraC.. Saviola B, Seabold R, Schleif RF;. J Mol Biol 1998;278:539-548. (from Pfam)

GO Terms: