Protein Family Models

Bacitracin resistance protein (BacA) is a putative undecaprenol kinase. BacA confers resistance to bacitracin, probably by phosphorylation of undecaprenol [1]. More recent studies show that BacA has undecaprenyl pyrophosphate phosphatase activity. Undecaprenyl phosphate is a key lipid intermediate involved in the synthesis of various bacterial cell wall polymers. Bacitracin, a mixture of related cyclic polypeptide antibiotics, is used to treat surface tissue infections. Its primary mode of action is the inhibition of bacterial cell wall synthesis through sequestration of the essential carrier lipid undecaprenyl pyrophosphate, C55-PP, resulting in the loss of cell integrity and lysis [2,3]. The characteristic phosphatase sequence-motif in this family is likely to be the PGxSRSGG, compared with the PSGH of the PAP family of phosphatases [3]. [1]. 8389741. Amplification of the bacA gene confers bacitracin resistance to Escherichia coli. Cain BD, Norton PJ, Eubanks W, Nick HS, Allen CM;. J Bacteriol 1993;175:3784-3789. [2]. 15138271. The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity. El Ghachi M, Bouhss A, Blanot D, Mengin-Lecreulx D;. J Biol Chem. 2004;279:30106-30113. [3]. 15778224. Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli. El Ghachi M, Derbise A, Bouhss A, Mengin-Lecreulx D;. J Biol Chem. 2005;280:18689-18695. (from Pfam)

Date:

2024-10-16

undecaprenyl-diphosphate phosphatase catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) and confers resistance to bacitracin

Date:

2022-08-30

Date:

2021-08-11

Date:

2021-08-25

Gene:

bacA

Date:

2021-10-20

This is a family of small, highly hydrophobic proteins. Overexpression of this protein in Escherichia coli is associated with bacitracin resistance, and the protein was originally proposed to be an undecaprenol kinase and called bacA. It is now known to be an undecaprenyl pyrophosphate phosphatase (EC 3.6.1.27) and is renamed UppP.

Gene:

uppP

Date:

2024-06-14