Protein Family Models

This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr [1]. [1]. 11807079. High genetic variability of the agr locus in Staphylococcus species. Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G;. J Bacteriol 2002;184:1180-1186. (from Pfam)

Gene:

agrD

Date:

2024-10-16

Members of this family of short peptides are precursors to thiolactone (unless Cys is replaced by Ser) cyclic autoinducer peptides, used in quorum-sensing systems in Gram-positive bacteria. The best characterized is the AgrD precursor, processed by the AgrB protein. Nearby proteins regularly encountered include a histidine kinase and a response regulator. This model is related to PF05931 but is newer and currently broader in scope.

Date:

2024-06-05

cyclic lactone autoinducer peptide similar to Staphylococcal AgrD protein, the precursor of the autoinducing peptide (AIP), which, by the action of AgrB, interacts with AgrC in the membrane to activate AgrA

Date:

2017-03-02