Protein Family Models

The bacterial sequences found in this family are similar to the N-terminal region of the TraG protein (Swiss:P33790). This is a membrane-spanning protein, with three predicted transmembrane segments and two periplasmic regions [1]. TraG protein is known to be essential for DNA transfer in the process of conjugation, with the N-terminal portion being required for F pilus assembly [1,2]. The protein is thought to interact with the periplasmic domain of TraN (Swiss:P24082) to stabilise mating-cell interactions [2]. [1]. 1348105. Characterization of the F plasmid bifunctional conjugation gene, traG. Firth N, Skurray R;. Mol Gen Genet 1992;232:145-153. [2]. 7915817. Analysis of the sequence and gene products of the transfer region of the F sex factor. Frost LS, Ippen-Ihler K, Skurray RA;. Microbiol Rev 1994;58:162-210. (from Pfam)

Date:

2024-10-16

conjugal transfer protein TraG N-terminal domain-containing protein; conjugal transfer mating pair stabilization protein TraG is required for two stages of the conjugation process, pilus biosynthesis and mating aggregate stabilization

Date:

2020-04-22