Protein Family Models

Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells. [1]. 9696746. Molecular characterization of a chromosomal determinant. conferring resistance to zinc and cobalt ions in Staphylococcus. aureus.. Xiong A, Jayaswal RK;. J Bacteriol 1998;180:4024-4029.. [2]. 8829543. Cloning and sequence analysis of czc genes in Alcaligenes sp.. strain CT14.. Kunito T, Kusano T, Oyaizu H, Senoo K, Kanazawa S, Matsumoto S;. Biosci Biotechnol Biochem 1996;60:699-704. (from Pfam)

Date:

2024-08-14

zinc transporter ZitB of the cation diffusion facilitator (CDF) family is involved in zinc efflux across the cytoplasmic membrane, reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc

Date:

2017-02-16

This HMM describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence.

Date:

2021-04-27

Gene:

zitB

Date:

2022-10-11