Protein Family Models for Protein (Select 658548294) - Protein Family Models

Select item 4447871.

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Family Accession:

Select item 4428602.

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Family Accession:

Select item 4123303.

This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC [1]. SecD and SecF are required to maintain a proton motive force [2]. [1]. 9694879. SecDF of Bacillus subtilis, a molecular Siamese twin required for the efficient secretion of proteins. Bolhuis A, Broekhuizen CP, Sorokin A, van Roosmalen ML, Venema G, Bron S, Quax WJ, van Dijl JM;. J Biol Chem 1998;273:21217-21224. [2]. 8112309. SecD and SecF are required for the proton electrochemical gradient stimulation of preprotein translocation. Arkowitz RA, Wickner W;. EMBO J 1994;13:954-963. (from Pfam)

Date:: 2025-02-01

Family Accession:: NF014416.5
Method:: HMM

Select item 4118014.

efflux RND transporter permease subunit

Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer [1]. [1]. 12374972. Crystal structure of bacterial multidrug efflux transporter AcrB. Murakami S, Nakashima R, Yamashita E, Yamaguchi A;. Nature 2002;419:587-593. (from Pfam)

GO Terms:

Cellular Component:: membrane (GO:0016020)

Molecular Function:: transmembrane transporter activity (GO:0022857)

Biological Process:: transmembrane transport (GO:0055085)

Date:: 2025-02-01

Family Accession:: NF013069.5
Method:: HMM

Select item 3900385.

new record, indexing in progress

Family Accession:

Select item 3891236.

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Family Accession:

Select item 3485597.

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Family Accession:

Select item 3466168.

new record, indexing in progress

Family Accession:

Select item 3400139.

efflux RND transporter permease subunit

efflux RND transporter permease subunit is an efflux membrane protein similar to Escherichia coli multidrug resistance protein MdtF, which is the inner membrane subunit of the tripartite efflux system MdtEF-TolC, which confers resistance to various compounds

Date:: 2022-08-26

Family Accession:: 17601054
Method:: Sparcle

Select item 2452510.

efflux RND transporter permease subunit

Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of Pfam HMM PF00873.

GO Terms:

Molecular Function:: efflux transmembrane transporter activity (GO:0015562)

Cellular Component:: membrane (GO:0016020)

Biological Process:: xenobiotic transport (GO:0042908)

Date:: 2024-06-24

Family Accession:: TIGR00915.1
Method:: HMM

Select item 2102011.

new record, indexing in progress

Family Accession:

Select item 2040612.

multidrug efflux RND transporter permease subunit

Multidrug efflux RND transporter permease subunits that belong to this family include OqxB, AcrB, AcrD, AcrF, MdtF, AdeE, AdeJ, MexB, etc.

GO Terms:

Molecular Function:: efflux transmembrane transporter activity (GO:0015562)

Cellular Component:: membrane (GO:0016020)

Biological Process:: xenobiotic transport (GO:0042908)

Biological Process:: transmembrane transport (GO:0055085)

Date:: 2022-10-11

Family Accession:: NF000282.2
Method:: HMM

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