Protein Family Models

Beta-galactosidases belong to glycosyl hydrolase 35 family (GH35) which catalyse the cleaveage of beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. These proteins consist of a catalytic TIM-barrel and two all-beta domains (ABD1 and ABD2) [1-5]. This entry represents the first all-beta domain ABD1. ABD2 is represented in Pfam:PF13364. Paper describing PDB structure 3thc. [1]. 22128166. Crystal structure of human beta-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases. Ohto U, Usui K, Ochi T, Yuki K, Satow Y, Shimizu T;. J Biol Chem. 2012;287:1801-1812. Paper describing PDB structure 4e8c. [2]. 22593580. Structural insights into the substrate specificity of Streptococcus pneumoniae beta(1,3)-galactosidase BgaC. Cheng W, Wang L, Jiang YL, Bai XH, Chu J, Li Q, Yu G, Liang QL, Zhou CZ, Chen Y;. J Biol Chem. 2012;287:22910-22918. Paper describing PDB structure 4mad. [3]. 25034434. Rational design of a glycosynthase by the crystal structure of beta-galactosidase from Bacillus circulans (BgaC) and its use for the synthesis of N-acetyllactosamine type 1 glycan structures. Henze M, You DJ, Kamerke C, Hoffmann N, Angkawidjaja C, Ernst S, Pietruszka J, Kanaya S, Elling L;. J Biotechnol. 2014;191:78-85. Paper describing PDB structure 6eon. [4]. 30349080. A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation. Cartmell A, Munoz-Munoz J, Briggs JA, Ndeh DA, Lowe EC, Basle A, Terrapon N, Stott K, Heunis T, Gray J, Yu L, Dupree P, Fernandes PZ, Shah S, Williams SJ, Labourel A, Trost M, Henrissat B, Gilbert H. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

Beta-galactosidase belongs to Glycoside hydrolase family 35 [1-5]. This entry represents the galactose-binding domain. Paper describing PDB structure 1tg7. [1]. 15491613. Crystal structures of beta-galactosidase from Penicillium sp. and its complex with galactose. Rojas AL, Nagem RA, Neustroev KN, Arand M, Adamska M, Eneyskaya EV, Kulminskaya AA, Garratt RC, Golubev AM, Polikarpov I;. J Mol Biol. 2004;343:1281-1292. Paper describing PDB structure 3og2. [2]. 21130883. Crystal structures of Trichoderma reesei beta-galactosidase reveal conformational changes in the active site. Maksimainen M, Hakulinen N, Kallio JM, Timoharju T, Turunen O, Rouvinen J;. J Struct Biol. 2011;174:156-163. Paper describing PDB structure 3thc. [3]. 22128166. Crystal structure of human beta-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases. Ohto U, Usui K, Ochi T, Yuki K, Satow Y, Shimizu T;. J Biol Chem. 2012;287:1801-1812. Paper describing PDB structure 4cu6. [4]. 25210925. Unravelling the multiple functions of the architecturally intricate Streptococcus pneumoniae beta-galactosidase, BgaA. Singh AK, Pluvinage B, Higgins MA, Dalia AB, Woodiga SA, Flynn M, Lloyd AR, Weiser JN, Stubbs KA, Boraston AB, King SJ;. PLoS Pathog. 2014;10:e1004364. Paper describing PDB structure 4e8c. [5]. 22593580. Structural insights into the substrate specificity of Streptococcus pneumoniae beta(1,3)-galactosidase BgaC. Cheng W, Wang L, Jiang YL, Bai XH, Chu J, Li Q, Yu G, Liang QL, Zhou CZ, Chen Y;. J Biol Chem. 2012;287:22910-22918. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

glycoside hydrolase family 35 protein such as beta-galactosidase that catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

Date:

2024-11-01