Protein Family Models for Protein (Select 690976562) - Protein Family Models

Select item 4374801.

lipase family alpha/beta hydrolase

lipase family alpha/beta hydrolase similar to triacylglycerol lipase that catalyzes the hydrolysis of triacylglycerol

Date:: 2024-04-29

Family Accession:: 18498059
Method:: Sparcle

Select item 4209692.

alpha/beta fold hydrolase

This family contains alpha/beta hydrolase enzymes of diverse specificity. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024109.5
Method:: HMM

Select item 4179583.

PGAP1-like protein

The sequences found in this family are similar to PGAP1 (Swiss:Q765A7). This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body [1]. This entry also includes Tgl2, a mitochondria protein that serves as a triacylglycerol lipase in budding yeasts [2]. [1]. 14734546. Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p. Tanaka S, Maeda Y, Tashima Y, Kinoshita T;. J Biol Chem. 2004;279:14256-14263. [2]. 19959834. The TGL2 gene of Saccharomyces cerevisiae encodes an active acylglycerol lipase located in the mitochondria. Ham HJ, Rho HJ, Shin SK, Yoon HJ;. J Biol Chem. 2010;285:3005-3013. (from Pfam)

GO Terms:

Molecular Function:: hydrolase activity, acting on ester bonds (GO:0016788)

Date:: 2024-10-16

Family Accession:: NF019436.5
Method:: HMM

Select item 4162684.

Putative serine esterase (DUF676)

This family of proteins are probably serine esterase type enzymes with an alpha/beta hydrolase fold. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF016915.5
Method:: HMM

Select item 4003555.