Protein Family Models

The founder member of this family is S. aureus sortase, a transpeptidase that attaches surface proteins by the threonine of an LPXTG motif to the cell wall [1]. [1]. 10427003. Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Mazmanian SK, Liu G, Ton-That H, Schneewind O;. Science 1999;285:760-763. [2]. 11239768. An embarrassment of sortases - a richness of substrates?. Pallen MJ, Lam AC, Antonio M, Dunbar K;. Trends Microbiol 2001;9:97-102. (from Pfam)

Date:

2024-10-16

class F sortase may function as a cysteine transpeptidase that cleaves a substrate protein at a conserved cell wall sorting signal and covalently links it to peptidoglycan; similar to Cutibacterium acnes class F sortase

Date:

2021-01-29