Protein Family Models

This is the N-terminal domain of the T6S-associated protein, TagF. A post-translational repressor of the hemolysin co-regulated secretion island I (HSI-I)-encoded type VI secretion system (H1-T6SS) found in Pseudomonas aeruginosa. The type VI secretion system (T6SS) is found broadly among the Proteobacteria and is implicated in diverse processes including host-cell interactions, biofilm formation and gene regulation. Furthermore, studies indicate that the T6SS plays a critical role in interbacterial interactions. TagF has been shown to regulate the activity of the H1-T6SS in a manner that does not require phosphorylated-Fha1, PpkA, or other Tag proteins. Additionally TagF is found to associate as a homodimer with nearly identical monomers composed of alpha and beta elements assembled as a three-layer sandwich (alpha-beta-alpha) [1]. [1]. 22017253. Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation. Silverman JM, Austin LS, Hsu F, Hicks KG, Hood RD, Mougous JD;. Mol Microbiol. 2011;82:1277-1290. (from Pfam)

Date:

2024-10-16

Members of this protein family are found exclusively, although not universally, in bacterial species that possess a type VI secretion system. Genes are found in type VI secretion-associated gene clusters. The specific function is unknown. This model represents the rather well-conserved amino-terminal domain of a protein family in which carboxy-terminal regions, when present, show little conservation.

Gene:

tagF

Date:

2019-09-10

type VI secretion system-associated protein similar to Pseudomonas Aeruginosa protein Pa0076

Date:

2019-10-04