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transaldolase family protein
Transaldolase (TAL) is an enzyme of the pentose phosphate pathway (PPP) found almost ubiquitously in the three domains of life (Archaea, Bacteria, and Eukarya). TAL shares a high degree of structural similarity and sequence identity with fructose-6-phosphate aldolase (FSA). They both belong to the class I aldolase family[4]. Their protein structures have been revealed[5]. [1]. 11705376. Snapshots of catalysis: the structure of. fructose-1,6-(bis)phosphate aldolase covalently bound to the. substrate dihydroxyacetone phosphate.. Choi KH, Shi J, Hopkins CE, Tolan DR, Allen KN;. Biochemistry 2001;40:13868-13875.. [2]. 11298760. Identification of catalytically important residues in the active. site of Escherichia coli transaldolase.. Schorken U, Thorell S, Schurmann M, Jia J, Sprenger GA,. Schneider G;. Eur J Biochem 2001;268:2408-2415.. [3]. 10869557. The three-dimensional structure of human transaldolase.. Thorell S, Gergely P Jr, Banki K, Perl A, Schneider G. FEBS Lett 2000;475:205-208.. [4]. 26131847. Converting Transaldolase into Aldolase through Swapping of the. Multifunctional Acid-Base Catalyst: Common and Divergent. Catalytic Principles in F6P Aldolase and Transaldolase.. Sautner V, Friedrich MM, Lehwess-Litzmann A, Tittmann K;. Biochemistry. 2015;54:4475-4486.. [5]. 25267444. Sweet siblings with different faces: the mechanisms of FBP and. F6P aldolase, transaldolase, transketolase and phosphoketolase. revisited in light of recent structural data.. Tittmann K;. Bioorg Chem. 2014;57:263-280. (from Pfam)
transaldolase A
transaldolase
transaldolase transfers a C3 ketol fragment from a ketose donor to an aldose acceptor as part of the non-oxidative branch of the pentose phosphate pathway
This family includes the majority of known and predicted transaldolase sequences, including E. coli TalA and TalB. It excluded two other families. The first includes E. coli transaldolase-like protein TalC. The second family includes the putative transaldolases of Helicobacter pylori and Mycobacterium tuberculosis.
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