Protein Family Models

Proteins containing this domain were originally annotated as basic membrane lipoproteins [1]. However, several proteins containing this domain were later predicted as ABC transporter substrate-binding proteins, such as PnrA (also known as TmpC or TP0319) and RfuA (also known as Tpn38 or TP0298) from Treponema pallidum. PnrA transports purine nucleosides [3], while RfuA transports riboflavin [4]. Proteins containing this domain also include Med from Bacillus subtilis. Med was annotated as a transcriptional activator protein that regulates comK [2]. This domain can also found at the N terminus of glutamate receptor-like proteins from Dictyostelium (slime mold) [5]. [1]. 9350727. Heterogeneity of BmpA (P39) among European isolates of Borrelia burgdorferi sensu lato and influence of interspecies variability on serodiagnosis. Roessler D, Hauser U, Wilske B;. J Clin Microbiol 1997;35:2752-2758. [2]. 9335269. A new Bacillus subtilis gene, med, encodes a positive regulator of comK. Ogura M, Ohshiro Y, Hirao S, Tanaka T;. J Bacteriol 1997;179:6244-6253. [3]. 16418175. The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum. Deka RK, Brautigam CA, Yang XF, Blevins JS, Machius M, Tomchick DR, Norgard MV;. J Biol Chem. 2006;281:8072-8081. [4]. 23404400. Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes. Deka RK, Brautigam CA, Biddy BA, Liu WZ, Norgard MV;. MBio. 2013;4:e00615-e00612. [5]. 17501984. GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation develo. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

BMP (basic membrane protein) family lipoprotein similar to Lactococcus cremoris ABC transporter nucleoside-binding protein BmpA and Listeria monocytogenes CD4+ T-cell-stimulating antigen; belongs to the type 1 periplasmic binding fold superfamily

Date:

2024-12-18