Protein Family Models

This family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases. [1]. 10373108. Structure of the Escherichia coli fumarate reductase respiratory complex. Iverson TM, Luna-Chavez C, Cecchini G, Rees DC;. Science 1999;284:1961-1966. (from Pfam)

Date:

2024-10-16

This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase. [1]. 8061609. Structure of glutathione reductase from Escherichia coli at 1.86 A resolution: comparison with the enzyme from human erythrocytes. Mittl PR, Schulz GE. Protein Sci 1994;3:799-809. (from Pfam)

Date:

2024-10-16

Catalyzes the formation of oxaloacetate from L-aspartate

Gene:

nadB

Date:

2021-07-29

L-aspartate oxidase catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+)

Date:

2023-03-06

L-aspartate oxidase is the B protein, NadB, of the quinolinate synthetase complex. Quinolinate synthetase makes a precursor of the pyridine nucleotide portion of NAD. This model identifies proteins that cluster as L-aspartate oxidase (a flavoprotein difficult to separate from the set of closely related flavoprotein subunits of succinate dehydrogenase and fumarate reductase) by both UPGMA and neighbor-joining trees. The most distant protein accepted as an L-aspartate oxidase (NadB), that from Pyrococcus horikoshii, not only clusters with other NadB but is just one gene away from NadA.

Gene:

nadB

Date:

2024-06-11