Protein Family Models

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001120) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. This family includes a protein from the burkholderic acid biosynthetic gene cluster from Burkholderia thailandensis E264 and appears to be predominantly found in Burkholderiaceae [1,2] [1]. 23055407. Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species. Franke J, Ishida K, Hertweck C;. Angew Chem Int Ed Engl. 2012;51:11611-11615. [2]. 22765305. Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens. Biggins JB, Ternei MA, Brady SF;. J Am Chem Soc. 2012;134:13192-13195. (from Pfam)

Date:

2024-10-16