Protein Family Models

This entry represents the C-terminal helical domain of CarD from Mycobacterium tuberculosis, a RNAP-binding protein that regulates transcription and essential processes [1-3]. This domain binds DNA in a non-specific manner [4]. [1]. 23858468. Structure and function of CarD, an essential mycobacterial transcription factor. Srivastava DB, Leon K, Osmundson J, Garner AL, Weiss LA, Westblade LF, Glickman MS, Landick R, Darst SA, Stallings CL, Campbell EA;. Proc Natl Acad Sci U S A. 2013;110:12619-12624. [2]. 24115125. Crystal structure of Mycobacterium tuberculosis CarD, an essential RNA polymerase binding protein, reveals a quasidomain-swapped dimeric structural architecture. Kaur G, Dutta D, Thakur KG;. Proteins. 2014;82:879-884. [3]. 22904282. Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis. Weiss LA, Harrison PG, Nickels BE, Glickman MS, Campbell EA, Darst SA, Stallings CL;. J Bacteriol. 2012;194:5621-5631. [4]. 29973616. Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils. Kaur G, Kaundal S, Kapoor S, Grimes JM, Huiskonen JT, Thakur KG;. Sci Rep. 2018;8:10124. (from Pfam)

Date:

2024-10-16

This is the RNA polymerase interacting domain (RID) of transcription-repair-coupling factor (TRCF), CarD and CarD homologue in Myxococcus xanthus, called CdnL. In Myxococcus xanthus, CdnL is a protein required for the activation of light- and starvation-inducible genes [1]. It interacts with the zinc-binding protein CarG to form a complex that regulates multiple processes in Myxococcus xanthus [4]. CarD is widely distributed among bacteria and represents a distinct class of RNAP binding proteins that regulate transcription and essential processes [4-8]. TRCF displaces RNA polymerase stalled at a lesion, binds to the damage recognition protein UvrA, and increases the template strand repair rate during transcription [3]. [1]. 8692912. High mobility group I(Y)-like DNA-binding domains on a bacterial transcription factor. Nicolas FJ, Cayuela ML, Martinez-Argudo IM, Ruiz-Vazquez RM, Murillo FJ;. Proc Natl Acad Sci U S A 1996;93:6881-6885. [2]. 11533063. Domain architecture of a high mobility group A-type bacterial transcriptional factor. Padmanabhan S, Elias-Arnanz M, Carpio E, Aparicio P, Murillo FJ;. J Biol Chem 2001;276:41566-41575. [3]. 7876261. Structure and function of transcription-repair coupling factor. I. Structural domains and binding properties. Selby CP, Sancar A;. J Biol Chem 1995;270:4882-4889. [4]. 16879646. Recruitment of a novel zinc-bound transcriptional factor by a bacterial HMGA-type protein is required for regulating multiple processes in Myxococcus xanthus. Penalver-Mellado M, Garcia-Heras F, Padmanabhan S, Garcia-Moreno D, Murillo FJ, Elias-Arnanz M;. Mol Microbiol. 2006;61:910-926. [5]. 20371514. CdnL, . TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

CarD family transcriptional regulator similar to Mycobacterium RNA polymerase-binding transcription factor CarD, an essential RNA polymerase binding protein that plays an important role in reprogramming the transcription machinery under diverse stress conditions

Date:

2016-03-07