Protein Family Models for Protein (Select 738449895) - Protein Family Models

Select item 4231261.

haloacid dehalogenase-like hydrolase

Date:: 2024-08-14

Family Accession:: NF024122.5
Method:: HMM

Select item 4230162.

HAD hydrolase-like protein

Date:: 2024-08-14

Family Accession:: NF024639.5
Method:: HMM

Select item 4220683.

HAD hydrolase-like protein

Date:: 2024-08-14

Family Accession:: NF024811.5
Method:: HMM

Select item 4112294.

HAD family hydrolase

This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain [1]. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria [2]. [1]. 8702766. Crystal structure of L-2-haloacid dehalogenase from Pseudomonas sp. YL. An alpha/beta hydrolase structure that is different from the alpha/beta hydrolase fold. Hisano T, Hata Y, Fujii T, Liu JQ, Kurihara T, Esaki N, Soda K;. J Biol Chem 1996;271:20322-20330. [2]. 20485265. A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. Osman C, Haag M, Wieland FT, Brugger B, Langer T;. EMBO J. 2010;29:1976-1987 (from Pfam)

Date:: 2024-10-16

Family Accession:: NF012905.5
Method:: HMM

Select item 3999505.