Protein Family Models

Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus [1,2]. [1]. 1860816. Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica. Michiels T, Vanooteghem JC, Lambert de Rouvroit C, China B, Gustin A, Boudry P, Cornelis GR;. J Bacteriol 1991;173:4994-5009. [2]. 22349221. Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system. Lountos GT, Tropea JE, Waugh DS;. Acta Crystallogr D Biol Crystallogr. 2012;68:201-209. (from Pfam)

Date:

2024-10-16

ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains. [1]. 1864505. Homology between proteins controlling Streptomyces fradiae tylosin resistance and ATP-binding transport. Rosteck PR Jr, Reynolds PA, Hershberger CL;. Gene 1991;102:27-32. [2]. 1977073. Structure and function of haemolysin B,P-glycoprotein and other members of a novel family of membrane translocators. Blight MA, Holland IB;. Mol Microbiol 1990;4:873-880. [3]. 2229036. Binding protein-dependent transport systems. Higgins CF, Hyde SC, Mimmack MM, Gileadi U, Gill DR, Gallagher MP;. J Bioenerg Biomembr 1990;22:571-592. [4]. 9872322. Crystal structure of the ATP-binding subunit of an ABC transporter. Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF, Kim SH;. Nature 1998;396:703-707. (from Pfam)

Date:

2024-10-16

The FHA (Forkhead-associated) domain is a phosphopeptide binding motif [2]. [1]. 7482699. The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Hofmann K, Bucher, P;. Trends Biochem Sci 1995;20:347-349. [2]. 10518219. The FHA domain is a modular phosphopeptide recognition motif. Durocher D, Henckel J, Fersht AR, Jackson SP;. Mol Cell. 1999;4:387-394. [3]. 12564991. Bacterial FHA domains: neglected players in the phospho-threonine signalling game?. Pallen M, Chaudhuri R, Khan A;. Trends Microbiol 2002;10:556-563. (from Pfam)

Date:

2024-10-16