U.S. flag

An official website of the United States government

Links from Protein

Items: 8

1.

beta-lactamase hydrolase domain-containing protein

This domain, once called DUF442, is found as the N-terminal region, a sulfur transferase domain, of the bifunctional protein Blh (from the former name beta-lactamase-like hydrolase). The longer C-terminal domain of Blh is a sulfur dioxygenase domain. An earlier study on the uncharacterized protein NMA1982 showed a structure similar to protein tyrosine phosphatases, and reportedly some activity was detected on the test substrate p-nitrophenyl phosphate. Consequently, proteins annotated by this HMM and the related HMM TIGR01244 have been annotated as phosphatases.

GO Terms:
Molecular Function:
hydrolase activity (GO:0016787)
Date:
2024-10-16
Family Accession:
NF016184.5
Method:
HMM
2.

MBL fold metallo-hydrolase

Date:
2024-08-14
Family Accession:
NF012955.5
Method:
HMM
3.
new record, indexing in progress
Family Accession:
4.
new record, indexing in progress
Family Accession:
5.
new record, indexing in progress
Family Accession:
6.
new record, indexing in progress
Family Accession:
7.

bifunctional sulfur transferase/dioxygenase Blh

Gene:
blh
Date:
2021-12-29
Family Accession:
NF040641.1
Method:
HMM
8.

TIGR01244 family sulfur transferase

Members of this family include NMA1982 from Neisseria meningitidis, which originally was called a phosphatase based on a fold similar to protein-tyrosine phosphatases and reportedly some activity on the phosphatase test substrate p-nitrophenyl phosphate. However, more recent work on the protein Blh from the plant pathogen Xylella fastidiosa showed that the N-terminal domain, covered by this HMM and by PF04273 (previously DUF442), acts as a sulfur transferase. The C-terminal domain of Blh (beta-lactamase-like hydrolase), with a metallo-beta-lactamase fold, was shown to act as a sulfur dioxygenase. The more recent work makes it seem likely that previous annotations of suggesting classification of member proteins as phosphatases were incorrect.

GO Terms:
Molecular Function:
hydrolase activity (GO:0016787)
Date:
2021-12-28
Family Accession:
TIGR01244.1
Method:
HMM

Supplemental Content

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center
External link. Please review our privacy policy.