Protein Family Models

NADP-dependent isocitrate dehydrogenase catalyzes the conversion of isocitrate to 2-oxoglutarate in an NADP-dependent manner

Date:

2024-02-09

NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes [2]. [1]. 8226630. Genes encoding two isocitrate dehydrogenase isozymes of a psychrophilic bacterium, Vibrio sp. strain ABE-1. Ishii A, Suzuki M, Sahara T, Takada Y, Sasaki S, Fukunaga N;. J Bacteriol 1993;175:6873-6880. [2]. 7836312. Cloning, sequence analysis, expression, and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme. Eikmanns BJ, Rittmann D, Sahm H;. J Bacteriol 1995;177:774-782. (from Pfam)

Date:

2024-10-16

The monomeric type of isocitrate dehydrogenase has been found so far in a small number of species, including Azotobacter vinelandii, Corynebacterium glutamicum, Rhodomicrobium vannielii, and Neisseria meningitidis. It is NADP-specific.

Date:

2021-04-27