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IS66 family insertion sequence element accessory protein TnpB
This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition [2]. [1]. 10489437. The Sinorhizobium meliloti insertion sequence (IS) element ISRm14 is related to a previously unrecognized IS element located adjacent to the Escherichia coli locus of enterocyte effacement (LEE) pathogenicity island. Schneiker S, Kosier B, Puhler A, Selbitschka W;. Curr Microbiol 1999;39:274-281. [2]. 11418571. Structural and functional characterization of IS679 and IS66-family elements. Han CG, Shiga Y, Tobe T, Sasakawa C, Ohtsubo E;. J Bacteriol 2001;183:4296-4304. (from Pfam)
transposase
transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism
IS66_ORF2.original: hypothetical protein
IS66_combined.original: hypothetical protein
The IS66 family insertion sequence element encodes a DDE transposase TnpC, and two accessory proteins, TnpA and TnpB. It has been assumed that the TnpA, TnpB, and TnpC proteins are produced independently in appropriate amounts and form a complex, which acts as a transposase to promote the transposition of an IS66 family element.
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